РОЛЬ ВАГИНАЛЬНОГО МИКРОБИОМА В РЕПРОДУКТИВНОЙ ФУНКЦИИ
DOI:
https://doi.org/10.47390/3030-3133V3I2Y2025N03Ключевые слова:
вспомогательные репродуктивные технологии, микробиом; неудачи имплантации; дисбактериоз; беременность, невынашивание.Аннотация
В последние годы микробиому человека уделяется все большее внимание. Создание технологии, основанной на секвенировании, позволило идентифицировать большое количество видов бактерий, которые ранее находились за пределами возможностей технологий, основанных на культивировании. Так же, как диагностика микробиома стала основным направлением в науке, репродуктивная медицина превратилась в предмет пристального интереса, особенно в отношении причинных исследований и вариантов лечения неудачи имплантации. Таким образом, вагинальный микробиом обсуждается как фактор, влияющий на бесплодие, и перспективная цель для вариантов лечения. В настоящем обзоре представлен обзор текущих исследований, касающихся влияния вагинального микробиома на результаты репродуктивных мер. Было показано, что микробиом, в котором не доминируют Lactobacillus, связан с дисбактериозом, возможно, даже с бактериальным вагинозом. Этот дисбаланс отрицательно влияет на показатели имплантации при вспомогательных репродуктивных технологиях, а также может быть причиной привычных абортов и невынашивание. Скрининг микробиома в сочетании с лечением антибиотиками и/или пробиотиками, по-видимому, является одним из способов улучшения результатов беременности.
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