THE ROLE OF APOLIPOPROTEIN E IN ATHEROSCLEROTIC RENAL ARTERY DISEASE
DOI:
https://doi.org/10.47390/Med-pro/v3i6y2025/N03Keywords:
chronic kidney disease, renal artery atherosclerosis, APOE, gene, polymorphismAbstract
Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide, with atherosclerosis being a major underlying pathology. Among the various manifestations of atherosclerosis, atherosclerotic renal artery disease (ARAD) is of particular clinical importance due to its association with renovascular hypertension, chronic kidney disease (CKD), and an increased risk of cardiovascular events. Despite advancements in diagnostic and therapeutic approaches, ARAD often progresses silently and is frequently diagnosed at advanced stages, making early identification of risk factors crucial
References
1. Sezer S, Tutal E, Arat Z, et al. Arterial atherosclerosis in patients with chronic kidney disease and its relationship with serum and tissue endothelin‑1. *J Ren Nutr.* (corrected). PMID: 19841523. ([PubMed][5])
2. Dhaun N, Webb DJ, Kluth DC. Endothelin‑1 and the kidney – beyond BP. *Br J Pharmacol.* 2012;167(4):720–731. ([NCBI][4])
3. Cho ME, Brunt VE, Shiu YT, et al. Endothelial dysfunction in chronic kidney disease: a clinical perspective. *Am J Physiol Heart Circ Physiol.* (PMC). ([PMC][2])
4. Endothelin-A receptor antagonism modifies cardiovascular risk factors in CKD. *PubMed.* PMID: 23243212. ([PubMed][7])
5. Namuun G, Kadota A, Hisamatsu T, et al. Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification. *J Atheroscler Thromb.* 2021;29(9):1359–1371. ([PMC][8])
6. Назарова, Н. О., & Жаббаров, О. О. (2025). РИСК АТЕРОСКЛЕРОЗА У ПАЦИЕНТОВ С ХРОНИЧЕСКОЙ БОЛЕЗНЬЮ ПОЧЕК.
7. Khaydarov, R., Umarova, Z. F., & Nazarova, N. O. (2025). RENAL HEMODYNAMIC CHANGES IN LUPUS NEPHRITIS. Медицинский журнал молодых ученых, (13 (03)), 216-220.
8. Nazarova, N. O., & Jabbarov, O. O. (2025). APOL1 NEPHROPATHY RISK VARIANTS AND INCIDENT CARDIOVASCULAR DISEASE EVENTS. Медицинский журнал молодых ученых, (13 (03)), 60-63.
9. Salimov, J. K., Umarova, Z. F., & Nazarova, N. O. (2025). THE USE OF ENOXAPARIN AND RIVAROXABAN IN PATIENTS WITH CHRONIC KIDNEY DISEASE. Инновационные исследования в современном мире: теория и практика, 4(3), 105-106