CHANGES IN THE INTESTINAL MICROFLORA OF A HEALTHY PERSON AND IN VARIOUS DISEASES
Keywords:
Microbiota; Dysbiosis; Celiac disease; Irritable bowel syndrome; Obesity.Abstract
Intestinal microbiota is a group of living microorganisms that live in the digestive system. Many research groups around the world are working to study the collective genome of the human microbiota. Modern methods of studying microbiota have made it possible to learn about the relationship between the number of bacteria and microorganisms living in the intestines and homeostasis. Microbiota is important for growth, development, immune development and nutrition of the body. The development of such common diseases as diabetes, obesity and bronchial asthma is explained, at least in part, by changes in the microbiota. Non-alcoholic fatty liver disease, celiac disease and irritable bowel syndrome along with a number of diseases of the gastrointestinal tract cause intestinal dysbiosis.
References
V. Ruiz Alvarez, Y. Puig Peña, M. Rodríguez AcostaMicrobiota intestinal, sistema inmune y obesidad Revista Cubana Invest Biomed (2012), 29 b.
W.B. Whitman, D.C. Coleman, W.J. Wiebe Prokaryotes: The unseen majority Proc Natl Acad Sci U S A, 95 (1998), 6578-6583 b.
J.F. Petrosino, S. Highlander, R.A. Luna, et al.Metagenomic pyrosequencing and microbial identification Clin Chem, 55 (2009), 856-866 b.
J. Peterson, S. Garges, M. Giovanni, et al., NIH HMP Working Group The NIH human microbiome project Genome Res, 19 (2009), 2317-2323 b.
Falony, G.; Joossens, M.; Vieira-Silva, S.; Wang, J.; Darzi, Y.; Faust, K.; Kurilshikov, A.; Bonder, M.J.; Valles-Colomer, M.; Vandeputte, D.; et al. Population-level analysis of gut microbiome variation. Science 2016, 352, 560–564 b.
Asnicar, F.; Berry, S.E.; Valdes, A.M.; Nguyen, L.H.; Piccinno, G.; Drew, D.A.; Leeming, E.; Gibson, R.; Le Roy, C.; Khatib, H.A.; et al. Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals. Nat. Med. 2021, 27, 321–332 b.
Stewart, C.J.; Ajami, N.J.; OʻBrien, J.L.; Hutchinson, D.S.; Smith, D.P.; Wong, M.C.; Ross, M.C.; Lloyd, R.E.; Doddapaneni, H.; Metcalf, G.A.; et al. Temporal development of the gut microbiome in early childhood from the TEDDY study. Nature 2018, 562, 583–588. [Google Scholar] [CrossRef] [PubMed]
Chen, L.; Wang, D.; Garmaeva, S.; Kurilshikov, A.; Vich Vila, A.; Gacesa, R.; Sinha, T.; Lifelines Cohort Study; Segal, E.; Weersma, R.K.; et al. The long-term genetic stability and individual specificity of the human gut microbiome. Cell 2021, 184, 2302–2315.e12. [Google Scholar] [CrossRef]
Ma, X.; Lu, X.; Zhang, W.; Yang, L.; Wang, D.; Xu, J.; Jia, Y.; Wang, X.; Xie, H.; Li, S.; et al. Gut microbiota in the early stage of Crohn’s disease has unique characteristics. Gut Pathog. 2022, 14, 46.
Di Cristanziano, V.; Farowski, F.; Berrilli, F.; Santoro, M.; Di Cave, D.; Glé, C.; Daeumer, M.; Thielen, A.; Wirtz, M.; Kaiser, R.; et al. Analysis of Human Gut Microbiota Composition Associated to the Presence of Commensal and Pathogen Microorganisms in Côte d’Ivoire. Microorganisms 2021, 9, 1763.
Andersen, L.O.; Bonde, I.; Nielsen, H.B.; Stensvold, C.R. A retrospective metagenomics approach to studying Blastocystis. FEMS Microbiol. Ecol. 2015, 91, fiv072. [Google Scholar] [CrossRef]
Nieves-Ramírez, M.E.; Partida-Rodríguez, O.; Laforest-Lapointe, I.; Reynolds, L.A.; Brown, E.M.; Valdez-Salazar, A.; Morán-Silva, P.; Rojas-Velázquez, L.; Morien, E.; Parfrey, L.W.; et al. Asymptomatic Intestinal Colonization with Protist Blastocystis is Strongly Associated with Distinct Microbiome Ecological Patterns. mSystems 2018, 3, e00007-18.
Castañeda, S.; Muñoz, M.; Villamizar, X.; Hernández, P.C.; Vásquez, L.R.; Tito, R.Y.; Ramírez, J.D. Microbiota characterization in Blastocystis-colonized and Blastocystis-free school-age children from Colombia. Parasites Vectors 2020, 13, 521.
Gut microbiota in health and disease Revista de Gastroenterología de México (English Edition), Volume 78, Issue 4, October–December 2013, 240-248b M.E. Icaza-Chávez
Flynn, K.J.; Ruffin, M.T.; Turgeon, D.K.; Schloss, P.D. Spatial Variation of the Native Colon Microbiota in Healthy Adults. Cancer Prev. Res. 2018, 11, 393–402.
Phipps, O.; Quraishi, M.N.; Dickson, E.A.; Steed, H.; Kumar, A.; Acheson, A.G.; Beggs, A.D.; Brookes, M.J.; Al-Hassi, H.O. Differences in the On- and Off-Tumor Microbiota between Right- and Left-Sided Colorectal Cancer. Microorganisms 2021, 9, 1108.
M. Rajilic-Stojanovic, E. Biagi, H.G.H.J. Heilig, et al. Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome Gastroenterology, 141 (2011), pp. 1792-1801
R. Spiller Review article: Probiotics and prebiotics in irritable bowel syndrome Aliment Pharmacol Ther, 28 (2008), pp. 385-396
M. Pimentel, E.J. Chow, H.C. Lin Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome: A double-blind, randomized, placebo-controlled study Am J Gastroenterol, 98 (2003), pp. 412-419
M. Pimentel, A. Lembo, W.D. Chey, et al. Rifaximin therapy for patients with irritable bowel syndrome without constipation N Engl J Med, 364 (2011), pp. 22-32 b.
Pastor-Villaescusa, B.; Blanco-Rojo, R.; Olivares, M. Evaluation of the Effect of Limosilactobacillus fermentum CECT5716 on Gastrointestinal Infections in Infants: A Systematic Review and Meta-Analysis. Microorganisms 2021, 9, 1412
Wolvers, D.; Antoine, J.M.; Myllyluoma, E.; Schrezenmeir, J.; Szajewska, H.; Rijkers, G.T. Guidance for substantiating the evidence for beneficial effects of probiotics: Prevention and management of infections by probiotics. J. Nutr. 2010, 140, 698S–712S.
Marfella R, Ferraraccio F, Rizzo MR, Portoghese M, Barbieri M, Basilio C, et al. Innate immune activity in plaque of patients with untreated and Lthyroxine-treated subclinical hypothyroidism. J Clin Endocrinol Metab (2011) 96(4):1015–20. doi: 10.1210/jc.2010-1382
Masetti G, Moshkelgosha S, Köhling HL, Covelli D, Banga JP, BerchnerPfannschmidt U, et al. Gut microbiota in experimental murine model of Graves’ orbitopathy established in different environments may modulate clinical presentation of disease. Microbiome (2018) 6(1):97. doi: 10.1186/ s40168-018-0478-4
Penhale WJ, Young PR. The influence of the normal microbial flora on the susceptibility of rats to experimental autoimmune thyroiditis. Clin Exp Immunol (1988) 72(2):288–92.
Köhling HL, Plummer SF, Marchesi JR, Davidge KS, Ludgate M. The microbiota and autoimmunity, Their role in thyroid autoimmune diseases. Clin Immunol (2017) 183:63–74. doi: 10.1016/j.clim.2017.07.001
Zhao F, Feng J, Li J, Zhao L, Liu Y, Chen H, et al. Alterations of the Gut Microbiota in Hashimotoʻs Thyroiditis Patients. Thyroid (2018) 28(2):175–86. doi: 10.1089/thy.2017.0395
Feng J, Zhao F, Sun J, Lin B, Zhao L, Liu Y, et al. Alterations in the gut microbiota and metabolite profiles of thyroid carcinoma patients. Int J Cancer (2019) 144(11):2728–45. doi: 10.1002/ijc.32007
Obanda, D.N.; Husseneder, C.; Raggio, A.M.; Page, R.; Marx, B.; Stout, R.W.; Guice, J.; Coulon, D.; Keenan, M.J. Abundance of the species Clostridium butyricum in the gut microbiota contributes to differences in obesity phenotype in outbred Sprague-Dawley CD rats. Nutrition 2020, 78, 110893
Lee, H.; An, J.; Kim, J.; Choi, D.; Song, Y.; Lee, C.-K.; Kong, H.; Kim, S.B.; Kim, K. A Novel Bacterium, Butyricimonas virosa, Preventing HFD-Induced Diabetes and Metabolic Disorders in Mice via GLP-1 Receptor. Front. Microbiol. 2022, 13, 8192
Wang, D.; Liu, C.-D.; Li, H.-F.; Tian, M.-L.; Pan, J.-Q.; Shu, G.; Jiang, Q.-Y.; Yin, Y.-L.; Zhang, L. LSD1 mediates microbial metabolite butyrate-induced thermogenesis in brown and white adipose tissue. Metabolism 2019, 102, 154011.
Sowah, S.A.; Riedl, L.; Damms-Machado, A.; Johnson, T.S.; Schübel, R.; Graf, M.; Kartal, E.; Zeller, G.; Schwingshackl, L.; Stangl, G.; et al. Effects of Weight-Loss Interventions on Short-Chain Fatty Acid Concentrations in Blood and Feces of Adults: A Systematic Review. Adv. Nutr. Int. Rev. J. 2019, 10, 673–684.
Citation: Liao, J.; Liu, Y.; Pei, Z.; Wang, H.; Zhu, J.; Zhao, J.; Lu, W.; Chen, W. Clostridium butyricum Reduces Obesity in a Butyrate-Independent Way. Microorganisms 2023, 11, 1292. https://doi.org/10.3390/ microorganisms11051292
Ridaura, V.K.; Faith, J.J.; Rey, F.E.; Cheng, J.; Duncan, A.E.; Kau, A.L.; Griffin, N.W.; Lombard, V.; Henrissat, B.; Bain, J.R.; et al. Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice. Science 2013, 341, 1241214.
Ottosson, F.; Brunkwall, L.; Ericson, U.; Nilsson, P.M.; Almgren, P.; Fernandez, C.; Melander, O.; Orho-Melander, M. Connection Between BMI-Related Plasma Metabolite Profile and Gut Microbiota. J. Clin. Endocrinol. Metab. 2018, 103, 1491–1501.
Castro-Nallar, E.; Shen, Y.; Freishtat, R.J.; Pérez-Losada, M.; Manimaran, S.; Liu, G.; Johnson, W.E.; Crandall, K.A. Integrating Microbial and Host Transcriptomics to Characterize Asthma-Associated Microbial Communities. BMC Med. Genom. 2015, 8, 1–9.
Birzele, L.T.; Depner, M.; Ege, M.J.; Engel, M.; Kublik, S.; Bernau, C.; Loss, G.J.; Genuneit, J.; Horak, E.; Schloter, M.; et al. Environmental and Mucosal Microbiota and Their Role in Childhood Asthma. Allergy Eur. J. Allergy Clin. Immunol. 2017, 72, 109–119.
