АSPECTS OF DIAGNOSIS OF CONNECTIVE TISSUE DYSPLASIA IN OBSTETRICS AND GYNAECOLOGY

Authors

  • Begoyim Bektemirova
  • Dilnoza Saidjalilova

DOI:

https://doi.org/10.47390/3030-3133V1I2Y2023N08

Keywords:

connective tissue dysplasia, magnesium, oxyproline, magnesium drugs, preterm birth, risk of pregnancy lost.

Abstract

The aim of the study is to study the effectiveness of determining the concentration of magnesium and oxyproline in the blood of pregnant women with undifferentiated connective tissue dysplasia (UCTD) and evaluate this with treatment with a magnesium preparation. The study was conducted in the obstetric complex No. 9 in Tashkent. It included 129 women. Of these, 65 were healthy women, and 64 had UCTD. The study showed that pregnant women with UCTD had higher blood levels of oxyproline and lower magnesium levels compared to the control group. Also, taking magnesium preparations led to the normalization of these indicators. It was found that in pregnant women with UCTD, determining the level of magnesium in the blood, as well as oxyproline, is considered important for pregnancy.

References

Boivin D.B., Boudreau P., Kosmadopoulos A. Disturbance of the Circadian System in Shift Work and Its Health Impact. J. Biol. Rhythm. 2022; 37:3–28. doi: 10.1177/07487304211064218.

Chaput J.P., McHill A.W., Cox R.C., Broussard J.L., Dutil C., da Costa B.G.G., Sampasa-Kanyinga H., Wright K.P., Jr. The role of insufficient sleep and circadian misalignment in obesity. Nat. Rev. Endocrinol. 2023; 19:82–97. doi: 10.1038/s41574-022-00747-7.

Chellappa S.L., Vujovic N., Williams J.S., Scheer F. Impact of Circadian Disruption on Cardiovascular Function and Disease. Trends Endocrinol. Metab. TEM. 2019; 30:767–779. doi: 10.1016/j.tem.2019.07.008.

Dun, A.; Zhao, X.; Jin, X.; Wei, T.; Gao, X.; Wang, Y.; Hou, H. Association between Night-Shift Work and Cancer Risk: Updated Systematic Review and Meta-Analysis. Front. Oncol. 2020, 10, 1006.

Dutheil F., Baker J.S., Mermillod M., De Cesare M., Vidal A., Moustafa F., Pereira B., Navel V. Shift work, and particularly permanent night shifts, promote dyslipidaemia: A systematic review and meta-analysis. Atherosclerosis. 2020; 313:156–169. doi: 10.1016/j.atherosclerosis.2020.08.015.

Fatima N., Rana S. Metabolic implications of circadian disruption. Pflug. Arch. Eur. J. Physiol. 2020; 472:513–526. doi: 10.1007/s00424-020-02381-6.

Fernandez R.C., Moore V.M., Marino J.L., Whitrow M.J., Davies M.J. Night Shift Among Women: Is It Associated with Difficulty Conceiving a First Birth? Front. Public Health. 2020; 8:595943. doi: 10.3389/fpubh.2020.595943.

Fishbein A.B., Knutson K.L., Zee P.C. Circadian disruption and human health. J. Clin. Investig. 2021;131: e148286. doi: 10.1172/JCI148286.

Gentry N.W., Ashbrook L.H., Fu Y.H., Ptáček L.J. Human circadian variations. J. Clin. Investig. 2021;131: e148282. doi: 10.1172/JCI148282.

Hulsegge G., Picavet H.S.J., van der Beek A.J., Verschuren W.M.M., Twisk J.W., Proper K.I. Shift work, chronotype and the risk of cardiometabolic risk factors. Eur. J. Public Health. 2019; 29:128–134. doi: 10.1093/eurpub/cky092.

Iwasaki M., Hirose T., Mita T., Sato F., Ito C., Yamamoto R., Someya Y., Yoshihara T., Tamura Y., Kanazawa A., et al. Morningness-eveningness questionnaire score correlates with glycated hemoglobin in middle-aged male workers with type 2 diabetes mellitus. J. Diabetes Investig. 2013; 4:376–381. doi: 10.1111/jdi.12047.

Khan S., Malik B.H., Gupta D., Rutkofsky I. The Role of Circadian Misalignment due to Insomnia, Lack of Sleep, and Shift Work in Increasing the Risk of Cardiac Diseases: A Systematic Review. Cureus. 2020;12: e6616. doi: 10.7759/cureus.6616.

Khosravipour M., Khanlari P., Khazaie S., Khosravipour H., Khazaie H. A systematic review and meta-analysis of the association between shift work and metabolic syndrome: The roles of sleep, gender, and type of shift work. Sleep Med. Rev. 2021; 57:101427. doi: 10.1016/j.smrv.2021.101427.

Klerman E.B., Brager A., Carskadon M.A., Depner C.M., Foster R., Goel N., Harrington M., Holloway P.M., Knauert M.P., LeBourgeois M.K., et al. Keeping an eye on circadian time in clinical research and medicine. Clin. Transl. Med. 2022;12: e1131. doi: 10.1002/ctm2.1131.

Koopman A.D.M., Rauh S.P., van ’t Riet E., Groeneveld L., van der Heijden A.A., Elders P.J., Dekker J.M., Nijpels G., Beulens J.W., Rutters F. The Association between Social Jetlag, the Metabolic Syndrome, and Type 2 Diabetes Mellitus in the General Population: The New Hoorn Study. J. Biol. Rhythm. 2017; 32:359–368. doi: 10.1177/0748730417713572.

Loloei S., Sepidarkish M., Heydarian A., Tahvilian N., Khazdouz M., Heshmati J., Pouraram H. The effect of melatonin supplementation on lipid profile and anthropometric indices: A systematic review and meta-analysis of clinical trials. Diabetes Metab. Syndr. 2019; 13:1901–1910. doi: 10.1016/j.dsx.2019.04.043.

Man A.W.C., Li H., Xia N. Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis. Int. J. Mol. Sci. 2021; 22:676. doi: 10.3390/ijms22020676.

Manouchehri E., Taghipour A., Ghavami V., Ebadi A., Homaei F., Latifnejad Roudsari R. Night-shift work duration and breast cancer risk: An updated systematic review and meta-analysis. BMC Women’s Health. 2021; 21:89. doi: 10.1186/s12905-021-01233-4.

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Published

2024-01-16

How to Cite

Bektemirova, B., & Saidjalilova, D. (2024). АSPECTS OF DIAGNOSIS OF CONNECTIVE TISSUE DYSPLASIA IN OBSTETRICS AND GYNAECOLOGY. MedicineProblems.Uz-Topical Issues of Medical Sciences, 1(2). https://doi.org/10.47390/3030-3133V1I2Y2023N08